Figure 8.
Transient times to approach steady-state for the basic and extended model. Parameter values for the basic model: λ−1 = 10 s−1,λ1 = 1μM−1s−1,k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 20μM−1s−1,k2 = 1 s−1,Pt = 1μM,St = 10μM.Parameter values for the extended model: λ−1 = 10 s−1,λ1 = 1μM−1s−1,k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 20μM−1s−1,k2 = 1 s−1,κ−1 = 50 s−1,κ1 = 1μM−1s−1,λ−3 = 10 s−1,λ3 = 1μM−1s−1,k3 = 100 s−1,Pt = 1μM,St = 10μM.The transient times for R = ([Sp] + [SpP] + [SpPK])/St were estimated such that the absolute difference between the positive steady-state and the time solution at the transient time is within a small tolerance and that the transient times do not change too much if the tolerance is varied. Hence, we chose the tolerance to be 10−4.