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. 2012 Apr 24;6:26. doi: 10.1186/1752-0509-6-26

Figure 9.

Figure 9

Transient phosphorylation of phosphoinositides due to enzymatic complex formation. Comparison of the two scenarios; solid line represent the case when a signalling trigger is simulated. Parameters used are the following: λ−1 = 10 s−1,λ1 = 1μM−1s−1,k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 1μM−1s−1,k2 = 1 s−1,κ−1=50s−1,κ1 = 1μM−1s−1,Kt = 0.1μM,Pt = 0.2μM,St = 300μM.The other parameters are λ−4 = 1 s−1,λ4 = 75μM−1s−1,k4 = 100 s−1for t≤300 s and λ−3 = 10 s−1,λ3 = 10μM−1s−1,k3 = 500 s−1, for t>300s. Dashed line represent the case when kinases are recruited linearly in time as Kt = 0.0003t. Other parameters used are the following: λ−1 = 10 s−1,λ1 = 1μM−1s−1,k1 = 1 s−1,λ−2 = 10 s−1,λ2 = 1μM−1s−1,k2 = 1 s−1,κ−1 = 50 s−1,κ1 = 1μM−1s−1,λ−3 = 10 s−1,λ3 = 10μM−1s−1,k3 = 500 s−1,Pt = 0.2μM,St = 300μM.