Figure 3.

Gradual deterioration of intracellular Ca²⁺ homeostasis during the development of cardiac dystrophy. Intracellular Ca²⁺ responses to osmotic shock (A), gain of EC-coupling (B), intracellular Ca²⁺ leak (C), and SR Ca²⁺ content (D) in WT and mdx cardiomyocytes isolated from 1-, 3–4-, and 12–15-month-old mice. Note the gradually increased SR Ca²⁺ leak and decreased SR Ca²⁺ load in mdx cardiomyocytes from older mice. The corresponding values are listed in Supplementary material online, Table S2.