Figure 2.

Tissue fungal burdens in the lungs of mice with invasive pulmonary aspergillosis 72 hours after infection. Tissue fungal burden was determined by real-time quantitative polymerase chain reaction with primers and probe specific for a sequence from the Aspergillus fumigatus 18S ribosomal RNA gene and expressed as conidial equivalents. Comparison of all treatment arms (30 mice per treatment arm) with the nonparametric Kruskal-Wallis test showed significant heterogeneity (P < .0001). Treatment arms that differed significantly from the saline control (Ctrl) or amphotericin B (AmB) treatment arms by the Dunn posttest are marked as **P < .001 and ***P < .0001. Abbreviations: bFGF, recombinant human basic fibroblast growth factor; VEGF, recombinant human vascular endothelial growth factor, proximal splice site 165.