Table 1.

Effect of increasing parameter values on model outputs for normal Aβ degradation rate (Model 2)

Parameter	Number of plaques (%)	Plaque size	Lag time
k dimer	Increases to max of 100	No effect	Decreases
k dedimer	Decreases	No effect	Increases
k pf	Increases to max of ~50	No effect	No effect
k pg	Small effect	Increases	No effect
k pghalf	Small effect	No effect	Slight decrease for large values
k disagg	No effect	Decreases	Increase at high values
k degNep	Increases	Increases	Decreases