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. Author manuscript; available in PMC: 2013 Feb 27.
Published in final edited form as: Clin Pharmacol Ther. 2008 Oct;84(4):506–512. doi: 10.1038/clpt.2008.102

Table 3.

Fexofenadine pharmacokinetic parameters

Control Acute ritonavir Steady-state
Ritonavir
Cmax (ng/ml) 194 ± 116 311±102a 191±95 b
AUC0-∞ (ng •hr •ml−1) 1010±460 2780±920a 1400 ± 700 b
AUC0-∞ ratio
(ritonavir/control)		 2.8 (2.2,3.6) 1.4 (1.1,1.7)
CL/F (ml•kg−1•mm−1) 15.5 ± 5.6 5.4 ± 1.9 a 10.7 ± 6.5 a b
Elimination t1/2 (hr) 10.6 ± 1.9 11.3 ± 2.5 10.4 ± 3.9

Results are the arithmetic mean ± SD (n=12), except the AUC0-∞ ratio (ritonavir/control), which is the geometric mean (90% CI)

a

Significantly different from control (p<0.05)

b

Significantly different from acute ritonavir (p<0.05)