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. Author manuscript; available in PMC: 2013 Feb 27.
Published in final edited form as: JACC Cardiovasc Imaging. 2011 Sep;4(9):1022–1039. doi: 10.1016/j.jcmg.2011.03.020

Figure 6. OCT Images and Corresponding Histopathology Demonstrating Collagen Birefringence In Atherosclerotic Plaques.

Figure 6

(A and E) Optical coherence tomography (OCT) images of fibrous plaques. (B) Polarization sensitive (PS)-OCT image of the fibrous plaque in A showing high birefringence as seen by the rapid transition of the image from black to white, corresponding to 0° to 180° phase retardation. (C) Picrosirius red stained histology section showing orange-red fibers (thicker fibers) under polarized light microscopy. (D and H) Trichrome stained histology images. (F) PS-OCT image of fibrous plaque showing black region corresponding to low birefringence below the luminal surface. (G) Corresponding picrosirius red stained histology section showing yellow-green fibers (thinner fibers) under polarized light microscopy. Scale bars = 500 µm. Reprinted with permission from Nadkarni et al. (37).