. Author manuscript; available in PMC: 2013 Feb 27.

Published in final edited form as: JACC Cardiovasc Imaging. 2011 Sep;4(9):1022–1039. doi: 10.1016/j.jcmg.2011.03.020

Table 1.

Summary of Many Key Features of Intravascular Optical Imaging Modalities Discussed, Including Mechanism, Measurement, Resolution, and Stage of Each Imaging Technology

Technology	Mechanism	Measurement	Resolution	Stage
Angioscopy	Superficial imaging	Surface structure composition	100 µm	Commercial, FDA approved
OCT/OFDI	Backscattering	Microstructure	10 µm	Commercial, FDA approved
PS-OCT	Birefringence	Collagen/SMC vs. lipid	10 µm	Pilot clinical studies
LSI	Speckle modulation	Biomechanics	100 µm	Ex vivo
NIRS	Absorption	Composition lipid	1 mm	Commercial, FDA approved
Raman	Inelastic scattering	Composition lipid	1 mm	Swine^*
TR-LIFS	Autofluorescence	Composition	100 µm	Rabbit
NIRF	Fluorescence	Molecular labels	100 µm	Rabbit

Indicates human xenograft.

FDA = Food and Drug Administration; LSI = laser speckle imaging; NIRF = near-infrared fluorescence; NIRS = near-infrared spectroscopy; OCT = optical coherence tomography; OFDI = optical frequency domain imaging; PS = polarization sensitive; SMC = smooth muscle cell; TR-LIFS = time-resolved laser-induced fluorescence spectroscopy.