Table 1. Genes identified as regulators of muscle protein degradation.
| (A) Genes contributing to acetylcholine control of proteasome mediated degradation17 | |
|---|---|
|
cha-1 |
Choline acetyltransferase |
|
unc-17 |
ACh vesicular transporter |
|
unc-13 |
Regulator of neurotransmitter release |
|
lev-1 |
AChR (non-α subunit) |
|
unc-29 |
AChR (non-α subunit) |
| unc-38 | AChR (α subunit) |
| (B) Genes contributing to Ras-MAPK control of autophagic degradation19 | |
|---|---|
|
let-60 |
Ras |
|
gap-1 |
Ras GTPase activating protein |
|
gap-2 |
Ras GTPase activating protein |
|
mpk-1 |
MAPK |
|
mek-2 |
MEK |
|
lin-45 |
Raf |
| gla-3 | TIS11 like zinc finger containing protein20 |
| (C) Genes contributing to FGF control of autophagic degradation upstream of Ras21 | |
|---|---|
|
clr-1 |
Tyrosine phosphatase |
|
egl-15 |
FGFR |
|
egl-17 |
FGF |
|
let-756 |
FGF |
|
sem-5 |
GRB2 |
| soc-2 | Leucine rich repeat protein |
| (D) Genes contributing to insulin-like control of autophagic degradation upstream of Raf22 | |
|---|---|
|
daf-2 |
IGFR |
|
age-1 |
PI3K |
|
pdk-1 |
3-phosphoinositide-dependent kinase 1 |
|
daf-18 |
PTEN |
| akt-1 | Akt |
| (E) Genes contributing to control of calpain-mediated degradation5 | |
|---|---|
|
pat-2 |
Integrin (α subunit) |
|
pat-3 |
Integrin (β subunit) |
|
pat-4 |
Integrin-linked kinase |
|
pat-6 |
α-parvin |
|
tln-1 |
Talin |
|
zyx-1 |
Zyxin |
|
atn-1 |
α-actinin |
|
cdc-42 |
Rho GTPase |
|
uig-1 |
Cdc-42 guanine nucleotide exchange factor |
|
deb-1 |
Vinculin |
|
unc-52 |
Perlecan |
|
unc-82 |
Kinase |
|
unc-97 |
PINCH-1 |
| unc-112 | Kindlin-2 |