Table 6.

Change-point analysis of the interaction of depression and social anxiety in BOLD responses to the social evaluative threat task

Region	x	y	z	voxels	vol (mm3)	Peak t	change-point onset	change-point offset	Control	Depression	Social Anxiety	Co-morbid
											Comorbid and/or Control > Depression and/or Social Anxiety
Instructions
l. Parahippocampal G	−40	−38	−2	34	918	7.3	65	82	2.52b	−6.09a	−8.17a	−1.43ab
l. Insula	−40	4	−2	28	756	6.84	64	69	7.10c	−8.56a	−5.08ab	−0.16b
l. Insula	−38	−16	8	15	405	5.77	70	78	3.26b	−6.15a	−6.46a	−2.08ab
l. Insula	−40	−8	20	195	5265	8.47	64	79	2.25b	−9.35a	−9.24a	−4.41a
r. Insula*	50	−14	14	30	810	5.78	65	71	2.56b	−7.62a	−7.50a	1.00b
l. Precentral G.	−38	8	22	15	405	5.99	65	75	0.03b	−4.14ab	−6.87a	0.26b
Early Speech Prep
l. Insula	−50	−34	22	36	972	5.89	115	121	9.46c	−11.72a	−1.47b	2.00b
Late Speech Prep
l. Lentiform Nucleus	−32	4	−2	15	405	5.58	148	157	3.51b	−3.26a	−3.48a	1.39ab
Recovery
l. Middle Temporal G.*	−44	−38	2	36	972	7.3	160	170	4.01b	−7.12a	−6.40a	2.08b
l. Precentral G.	−38	−14	32	23	621	7.07	164	177	4.36b	−8.80a	−4.96a	−3.08a
Depression and/or Social Anxiety > Comorbid and/or Control
Instructions
Cerebellum: Declive*	8	−62	−20	14	378	−5.38	90	95	−7.42a	10.43c	26.22d	2.94b
Cuneus*	−8	−68	4	446	12042	−7.94	65	84	3.28a	27.79c	29.39c	12.44b
r. Inferior Frontal G.	40	20	−10	15	405	−6.07	69	81	−11.20a	7.13c	−4.78b	−8.58ab
r. Insula	40	4	−4	23	621	−6.57	71	84	−11.09a	8.04b	−7.03a	−7.09a
r. Cuneus*	22	−76	8	37	999	−6.06	67	79	−1.70a	15.35b	21.56c	3.66a
Early Speech Prep
No suprathreshold voxels
Late Speech Prep
No suprathreshold voxels
Recovery
Lingual G.	8	−56	−4	448	12096	−7.4	161	172	−3.95a	27.24c	18.43bc	16.44b
Precuneus*	−2	−68	26	21	567	−6.21	164	171	−6.24a	24.31c	23.38c	12.11b

Note. These clusters were masked with the clusters that exhibited group average activation differences during the social evaluative threat task. vol = volume; G. = Gyrus. Different subscripts represent significantly differences between the groups, calculated using simple slopes analyses on the beta coefficients (presented here) from the multiple regression models.

* Those regions for which comorbid participants’ activation significantly differed from both pure depression and pure social anxiety groups.