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Relationship between integrin expression and metastatic potential of B16 cells. Cells were transfected once (A) or twice (B) with 25 nM of siRNA for integrin β3. Mice were inoculated intravenously with 3×105 cells. Twenty-one days after inoculation of B16 cells, lungs were excised and weighed immediately, and lung metastatic foci were counted. Values are mean ± SD. n=7 (A) or n=8 (B), *p<0.01 assessed with Kruskal-Wallis ANOVA.
