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The AhR binds the putative XRE cassette located upstream of the Stc2 transcriptional start site. ChIP analysis of AhR protein binding to the Stc2 promoter region in liver tissue from AhRfx/fx (A) or AhR CKO (B) mice treated with vehicle (-) or 20 μg/kg TCDD (+) for 2 hours. IgG and histone H3 antibodies were used as negative and positive controls, respectively. The primers used for ChIP analysis correspond to base pairs -473 to -453 (For) and -182 to -161 (Rev).
