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Schematic diagram depicting the mechanism of action of UCD38B. UCD38B binds to intracellular uPA, causing its translocation to perinuclear mitochondria and triggering a reduction in the mitochondrial membrane potential MMP. AIF is subsequently released from mitochondria and nuclearly translocated to cause caspase-independent necrosis. AIF-mediated necroptosis triggered by UCD38B appears to be independent of PARP activation or H2AX phosphorylation.
