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Development of a HTS compatible β-arrestin recruitment assay for human GPR35. Concentration-response curves for agonist hits identified from a pilot screen of NINDS/Sequoia compound libraries were performed using the human GPR35 PathHunter β-arrestin recruitment assay. Data are expressed as % of the response to 100 µM zaprinast. pEC50 values for each compound are provided in parentheses. Data are means ± S.E.M. from two separate experiments performed in duplicate.
