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Analogs of compound 1 are also potent agonists of human GPR35. (A) The potency of compound 1 (circles) was compared with that of the related analogs, compounds 6 (squares) and 7 (triangles) as well as zaprinast (diamonds) in the human GPR35 PathHunter β-arrestin recruitment assay. (B) By using the BRET-based β-arrestin-2 interaction assay the potency of these ligands were compared at human, rat, and mouse GPR35. Data are means ± S.E.M., n = 3.
