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Brain and plasma concentration versus time profiles of dabrafenib. Brain and plasma concentrations of dabrafenib after an i.v. dose of 2.5 mg/kg in FVB wild-type mice at 5, 15, 30, 60, and 120 minutes postdose. Brain concentrations of dabrafenib are significantly lower than plasma concentrations at all measured time points. Data represent the mean ± S.D.; n = 3–4. *P < 0.05; **P < 0.001; ***P < 0.0001.
