Fig. 2.

(Left panels) Dose-effect functions of CB₁ agonist ligands in subjects trained to discriminate 0.01 mg/kg AM4054 from saline. Abscissae, cumulative dose, log scale; ordinate, percent of responses on the AM4054-associated lever (top-left panel), response rate (bottom-left panel). Open symbols left of abscissae break indicate performance during saline (S) and AM4054 (AM) control sessions. Points represent averages (± S.E.M.) for the groups of subjects. (Right panels) Dose-effect functions of non-CB₁ agonist ligands in subjects trained to discriminate 0.01 mg/kg AM4054 from saline. Abscissae, cumulative dose, log scale; ordinate, percent of responses on the AM4054-associated lever (top-right panel), response rate (bottom-right panel). Open symbols left of abscissae break indicate performance during saline (S) and AM4054 (AM) control sessions. Points represent averages (± S.E.M.) for the groups of subjects.