Fig. 3.

Dose-effect functions of AM4054 in subjects trained to discriminate 0.01 mg/kg AM4054 from saline either alone (open symbols) or after several pretreatment doses of SR141716A (left panels) and AM4113 (right panels). Abscissae, cumulative dose, log scale; ordinate, percent of responses on the AM4054-associated lever (top-left panel), response rate (bottom-left panel). Open symbols left of abscissae break indicate performance during saline (S) and AM4054 (AM) control sessions. Points represent averages (± S.E.M.) for the groups of subjects.