Fig. 2.

(A) EC proliferation data are exemplified with dose-response curves for DBF-based compounds 6DBF7, DB16, and DB21 as labeled. Proliferation of basic fibroblast growth factor–stimulated (10 ng/ml) HUVEC cultures was measured by colorimetric quantification. (B) EC proliferation results from alanine scanning of 6DBF7 are shown in bar graph format as the ratio of IC₅₀ values (from Table 1) for DB analogs (DB1–DB13) divided by that of the parent 6DBF7. For reference, the chemical structure of 6DBF7 is shown as an inset.