FIGURE 1.
LeTx activates Kir and Kv channels in an alveolar macrophage cell line. A, Typical current recordings from MH-S cells under control and LeTx 100 ng/ml (LF and PA) treatment. B, Dose-response effect of LeTx on Kir current density. The currents were measured at −95 mV. C, Dose-response effect of LeTx on Kv currents measured at +60 mV. Each data set represents 4–15 independent experiments with 12–45 cells per condition and is expressed as mean ± SEM. The Kir and Kv current density was significantly increased in cells treated with LF and PA at 100 ng/ml each, when compared with the untreated control. ***p < 0.001.