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. Author manuscript; available in PMC: 2013 Feb 27.
Published in final edited form as: J Immunol. 2011 Mar 18;186(9):5236–5243. doi: 10.4049/jimmunol.1001078

FIGURE 2.

FIGURE 2

LeTx-induced activation of Kir and Kv channels is specifically blocked by Ba2+ and by 4-AP, respectively. A, Overlays of typical current recordings from MH-S cells in control cells and in cells treated with 100 ng/ml LeTx (LF and PA) recorded in the absence of channel blockers (upper panel), in the presence of 300 μM Ba2+ to block Kir channels (middle panel), and in the presence of 3 mM 4-AP to block Kv channels (lower panel). B, Mean Kir current densities (−95 mV) in the six experimental cell populations described above. C, Mean Kv current densities (+60 mV) in the same experimental cell populations. Each data set is expressed as mean ± SEM. All experiments were repeated with three to five independent cell populations with 5–30 cells per condition. ***p < 0.001.