Figure 4.

Quantification of metastasized tumor cell amounts in para-aortic lymph node (A) and lung (B) of mice with the HT-29 rectal xenografts treated with various concentrations of celecoxib. The amount of metastasized tumor cells was calculated by amplification of the human β-globin gene and shown as the number of tumor cells in the organ. Celecoxib inhibited lymph node and lung metastases in mice with rectal xenograft in a dose-dependent manner.