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. 2012 Jun 26;28(3):777–784. doi: 10.3892/or.2012.1885

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Copyright © 2012, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Effect of celecoxib on angiogenesis in rectal xenograft. (A) Representative micrograph of immunohistochemistry with an anti-mouse CD31 antibody of the rectal xenograft of a mouse treated with vehicle and celecoxib-treated mouse. Black arrows show CD31-positive microvessels. Scale bar, 100 μm. (B) Vascularity was measured by the average number of vessels per field counted in 8 random areas at ×20 magnification. MVD was calculated as the average number of vessels per mm². Celecoxib significantly inhibited angiogenesis in the rectal xenograft.

Effect of celecoxib on angiogenesis in rectal xenograft. (A) Representative micrograph of immunohistochemistry with an anti-mouse CD31 antibody of the rectal xenograft of a mouse treated with vehicle and celecoxib-treated mouse. Black arrows show CD31-positive microvessels. Scale bar, 100 μm. (B) Vascularity was measured by the average number of vessels per field counted in 8 random areas at ×20 magnification. MVD was calculated as the average number of vessels per mm². Celecoxib significantly inhibited angiogenesis in the rectal xenograft.