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Effect of celecoxib on tumor cell apoptosis in rectal xenograft as detected by TUNEL assay. (A) Representative micrograph of TUNEL assay in the rectal xenograft of a mouse treated with vehicle and celecoxib-treated mouse. Black arrow shows the apoptotic cells. Scale bar, 50 μm. (B) The apoptotic index was calculated as follows: apoptotic index (%) = (no. of apoptotic cells/no. of total tumor cells × 100). Celecoxib significantly induced tumor cell apoptosis.
