Table III.
Effect of celecoxib on PGE2 production, angiogenesis and apoptosis induction in human colon cancer xenograft.
| Median (range) | ||||
|---|---|---|---|---|
|
|
||||
| Vehicle (n=10) | 1500 ppm celecoxib (n=10) | P-value | Relative valuea | |
| PGE2 production (ng/ml) | 1647 (1125–13030) | 100.3 (8.14–509) | 0.000157 | 0.684 |
| MVD counting (/mm2) | 56 (32–80) | 27 (9–42) | 1.33×10−12 | 0.482 |
| Apoptosis index (%) | 1.64 (0.82–8.2) | 4.1 (1.64–11.5) | 3.00×10−14 | 2.5 |
a
Relative value is calculated as the value in celecoxib-treated mice compared to that in vehicle-treated mice.