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Akt isoforms expression and compartmentalization in a group of patients with HER2-positive metastatic breast cancer.
| Akt isoform | IHC staining | No. of patients | % |
|---|---|---|---|
| Akt1 | Negative | 17 | 23.0 |
| Weak | 46 | 62.1 | |
| Strong | 9 | 12.2 | |
| NA | 2 | 2.7 | |
| Akt2 | Negative | 0 | |
| Weak | 45 | 60.8 | |
| Strong | 26 | 35.1 | |
| NA | 3 | 4.1 | |
| pAkt Thr308 | Negative | 10 | 13.5 |
| Cytoplasmic only | 22 | 29.7 | |
| Nuclear and cytoplasmic | 38 | 51.4 | |
| NA | 4 | 5.4 | |
| pAkt Ser473 | Negative | 5 | 6.8 |
| Cytoplasmic only | 16 | 21.6 | |
| Nuclear and cytoplasmic | 49 | 66.2 | |
| NA | 4 | 5.4 |
NA, not assessed; no., number.
