Figure 5.

CD82 attenuates Wnt signalling at multiple levels (working hypothesis). CD82 attenuates Wnt signalling in multiple ways: i) inhibition of β-catenin nuclear translocation by downregulation of Fzd receptors or other mechanism; ii) accumulation of β-catenin in the cytoplasm is accelerated by downregulation of GSK-3β and CK1α; iii) recruitment of β-catenin to the cell membrane by stabilization of the E-cadherin-β-catenin complex by inhibition of RTK and downregulation of CK1α; and iv) CD82 induces exosomal β-catenin release as described by Chairoungdua et al(41).