Figure 2.
Dietary resveratrol did not sensitize t(4;11) ALL cells to vincristine treatment. Mice were fed control or resveratrol supplemented diets (n=16 per group) for 3 weeks prior to injection of 5×106 SEM leukemia cells into the tail vein. Mice were monitored for engraftment of the leukemia by flow cytometry beginning at 2 weeks after injection of the leukemia cells as described in Fig. 1. Arrows indicate the initiation of vincristine treatment at a dose of 0.5 mg/kg body weight 3 times per week. (A), Represents data for all mice in each group. One mouse in the resveratrol fed group had a leukemia burden of approximately 10% and showed a delayed response to the vincristine treatment, resulting in the large standard error at week 5. (B), Represents data shown in (A) minus the highly engrafted mouse, indicating that vincristine was similarly effective in reducing the leukemic burden in both groups. Data are presented as mean ± SEM. No differences in the percentage of CD19+ cells between the dietary groups was observed (2-way ANOVA, P=0.39 using all mice in each group).