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. 2013 Mar 1;24(5):643–658. doi: 10.1091/mbc.E12-09-0659

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© 2013 Baetz and Goldenring. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — EGFP–Rab11-FIPs in live HeLa cells occupy distinct compartments. (A) Schematic representations of the Rab11-FIPs examined in the present study, the names used for each of the proteins in this and other studies, and a general outline of previously characterized regions within these proteins. Time-lapse images of each Rab11-FIP condition were collected, and representative single frames are presented for each condition in B. Corresponding time-lapse videos for the Rab11-FIP1 proteins and Rab11a are presented in Supplemental Video S1. Two general phenotypic differences were observed in FIP localization and movement. FIP1A, FIP2, and FIP5 maintain a wide distribution, similar to that observed for Rab11a. FIP1B, FIP1C, and FIP3 are primarily more centralized in localization. In addition, FIP1C and FIP3 displayed evidence of branching tubules emanating from the central perinuclear region. Data represent at least three independent experiments. Bars, 10 μm.