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. 2012 Aug 21;41(5):1577–1586. doi: 10.3892/ijo.2012.1594

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Copyright © 2012, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Figure 1. — IL-22R is expressed in the OSCC of the extirpated samples and OSCC cell lines. (A) IL-22R immunostaining was observed in four of the seven extirpated samples, including some normal regions. The immunoreactive intensity for IL-22 was increased in the OSCC region (right side; *) compared with that in the normal oral epithelium (left side). Scale bar, 100 μm. (B) Metastatic carcinoma cells in the cervical lymph node (**) showed strongly positive signals for IL-22R (arrow). Scale bar, 1 mm. (C) IL-22R positive signals in metastatic carcinoma cells in the cervical lymph node (**) in another case. Scale bar, 100 μm. (D) IL-10R2 and IL-22R1 mRNA expressions were examined by semiquantitative RT-PCR. β-actin was used as an internal control.