Table 1.
Characteristics of studies on the association between MTHFR 677C>T polymorphism and cervical cancer
| Author (year) | Ethnicity | Country | Study design | Cases | Controls | Genotype method† | Genotype frequency (TT:CT:CC) | Confounding factors | PHWE* | Quality score |
|---|---|---|---|---|---|---|---|---|---|---|
| Lambropoulos 2003 [43] |
Europeans |
Greece |
Hospital-based case–control study |
21 cases with cervical cancer |
91 non-cancer controls |
PCR-RFLP |
(case) 2:8:11 (control) 12:37:42 |
None |
0.40 |
5 |
| Sull 2004 [45] |
East Asians |
South Korea |
Hospital-based case–control study |
246 cases with invasive cervical cancer |
454 healthy controls |
PCR-RFLP |
(case) 58:115:73 (control) 80:221:153 |
Age, weight |
0.99 |
7 |
| Zoodsma 2005 [18] |
Europeans |
Netherlands |
Hospital-based case–control study |
636 cases with cervical cancer |
592 unrelated controls |
PCR-RFLP |
(case) 49:230:357 (control) 57:262:273 |
None |
0.61 |
6 |
| Kang 2005 [42] |
East Asians |
South Korea |
Hospital-based case–control study |
79 cases with invasive cervical cancer |
74 healthy controls |
PCR-RFLP |
(case) 20:32:27 (control) 12:32:30 |
Age |
0.49 |
7 |
| Delgado 2006 [12] |
Others |
Mexico |
Hospital-based case–control study |
70 cases with cervical cancer |
89 non-cancer controls |
PCR-RFLP |
(case) 18:34:18 (control) 20:49:20 |
None |
0.34 |
5 |
| Ma 2006 [44] |
East Asians |
China |
Hospital-based case–control study |
111 cases with cervical cancer |
111 controls with hysteromyoma |
PCR-RFLP |
(case) 38:53:20 (control) 18:60:33 |
Age |
0.29 |
4 |
| Shekari 2008 [16] |
Indians |
India |
Hospital-based case–control study |
200 cases with cervical cancer |
200 non-cancer controls |
PCR-RFLP |
(case) 2:28:170 (control) 7:68:125 |
Age, menopause |
0.54 |
8 |
| Kohaar 2010 [13] |
Indians |
India |
Hospital-based case–control study |
203 cases with cervical cancer |
231 healthy controls |
PCR-RFLP |
(case) 4:58:141 (control) 5:65:161 |
Age |
0.59 |
6 |
| Prasad 2011 [15] |
Indians |
India |
Hospital-based case–control study |
62 cases with cervical cancer |
241 non-cancer controls |
PCR-RFLP |
(case) 0:5:57 (control) 1:12:228 |
None |
0.07 |
5 |
| Mostowska 2011 [14] |
Europeans |
Poland |
Hospital-based case–control study |
124 cases with cervical cancer |
168 healthy controls |
PCR-RFLP |
(case) 9:59:56 (control) 18:81:69 |
Parity |
0.42 |
7 |
| Tong 2011 [17] | East Asians | South Korea | Hospital-based case–control study | 146 cases with advanced cervical cancer | 427 unrelated healthy female volunteers | PCR-RFLP | (case) 28:65:53 (control) 77:198:152 | Age | 0.37 | 8 |
(†PCR-RFLP, Polymerase chain reaction restriction fragment length polymorphism; *P HWE was for the P value of Hardy-Weinberg equilibrium.)