Table 2.
Odds ratios and heterogeneity results in the meta-analysis of the association between MTHFR 677C>T polymorphism and cervical cancer
|
Contrast model |
Studies (participants) |
Fixed effects model |
Random effects model |
PH‡ |
I2(%) |
||
|---|---|---|---|---|---|---|---|
| OR[95%CI]* | POR | OR[95%CI] | POR | ||||
|
Total studies# |
|
|
|
|
|
|
|
| TT versus CC |
11(4,576) |
1.05(0.85-1.30) |
0.644 |
1.06(0.72-1.56) |
0.773 |
0.008 |
58.2% |
| CT versus CC |
11(4,576) |
0.81(0.70-0.92) |
0.002 |
0.86(0.67-1.11) |
0.247 |
0.002 |
63.5% |
| TT + CT versus CC |
11(4,576) |
0.83(0.73-0.95) |
0.005 |
0.90(0.68-1.20) |
0.481 |
<0.001 |
73.3% |
| TT versus CT + CC |
11(4,576) |
1.14(0.94-1.38) |
0.171 |
1.14(0.84-1.54) |
0.412 |
0.052 |
45.1% |
|
Caucasians |
|
|
|
|
|
|
|
| T versus C |
6(2,769) |
0.74(0.65-0.84) |
<0.001 |
0.74(0.54-1.01) |
0.056 |
0.004 |
71.0% |
| TT versus CC |
6(2,769) |
0.63(0.45-0.88) |
0.007 |
0.64(0.45-0.89) |
0.009 |
0.794 |
0.0% |
| CT versus CC |
6(2,769) |
0.69(0.58-0.82) |
<0.001 |
0.74(0.50-1.09) |
0.122 |
0.003 |
71.7% |
| TT + CT versus CC |
6(2,769) |
0.68(0.58-0.80) |
<0.001 |
0.71(0.49-1.04) |
0.082 |
0.003 |
72.8% |
| TT versus CT + CC |
6(2,769) |
0.73(0.52-1.01) |
0.056 |
0.73(0.53-1.02) |
0.067 |
0.871 |
0.0% |
|
East Asians |
|
|
|
|
|
|
|
| T versus C |
4(1,648) |
1.24(1.07-1.44) |
0.004 |
1.28(1.02-1.62) |
0.034 |
0.092 |
53.5% |
| TT versus CC |
4(1,648) |
1.56(1.17-2.08) |
0.003 |
1.66(1.05-2.62) |
0.029 |
0.097 |
52.6% |
| CT versus CC |
4(1,648) |
1.08(0.85-1.37) |
0.514 |
1.08(0.85-1.37) |
0.518 |
0.754 |
0.0% |
| TT + CT versus CC |
4(1,648) |
1.20(0.96-1.50) |
0.102 |
1.21(0.95-1.54) |
0.120 |
0.340 |
10.6% |
| TT versus CT + CC |
4(1,648) |
1.51(1.17-1.94) |
0.001 |
1.55(1.09-2.22) |
0.016 |
0.157 |
42.4% |
|
Europeans |
|
|
|
|
|
|
|
| T versus C |
3(1,632) |
0.77(0.66-0.89) |
0.001 |
0.77(0.66-0.89) |
0.001 |
0.828 |
0.0% |
| TT versus CC |
3(1,632) |
0.65(0.45-0.93) |
0.020 |
0.65(0.45-0.93) |
0.020 |
0.991 |
0.0% |
| CT versus CC |
3(1,632) |
0.71(0.58-0.88) |
0.002 |
0.71(0.58-0.88) |
0.002 |
0.552 |
0.0% |
| TT + CT versus CC |
3(1,632) |
0.70(0.58-0.86) |
<0.001 |
0.70(0.58-0.86) |
<0.001 |
0.658 |
0.0% |
| TT versus CT + CC |
3(1,632) |
0.75(0.53-1.07) |
0.113 |
0.75(0.53-1.07) |
0.113 |
0.922 |
0.0% |
|
Indians§ |
|
|
|
|
|
|
|
| TT versus CC |
3(1,137) |
0.51(0.20-1.30) |
0.157 |
0.54(0.19-1.59) |
0.260 |
0.321 |
12.0% |
| TT versus CT + CC | 3(1,137) | 0.57(0.22-1.46) | 0.239 | 0.60(0.23-1.59) | 0.305 | 0.471 | 0.0% |
(*OR = Odds Ratio; 95%CI = 95% Confidence Interval; † random = random-effects model; fixed = fixed-effects model; ‡PH, the P value of heterogeneity; # the data was not pooled in the analysis of the allele contrast model (T versus C) owing to the high heterogeneity (I2 = 79.8%); § the data was not pooled in the analyses of the allele contrast model (T versus C, I2 = 87.7%), heterozygote (CT versus CC, I2 = 87.8%), and dominant (TT and CT versus CC, I2 = 88.5%) models owing to the high heterogeneity.)