Table 3.
The frequencies of genotypes among CDH1 methylated and unmethylated groups
| CDH1 unmethylated | CDH1 methylated | p value* | |
|---|---|---|---|
| the number of subjects |
281 |
246 |
|
| mean age ± SD |
60.6 ± 14.0 |
61.4 ± 13.3 |
NS |
| male : female |
165 : 116 |
154 : 92 |
NS |
|
H. pylori positivity |
152/281 |
186/246 |
<0.0001 |
| non-GC : GC |
262 : 19 |
150 : 96 |
<0.0001 |
| HRH2 rs2607474 genotype |
|
|
|
| G/G |
197 |
204 |
0.013# |
| G/A |
78 |
41 |
|
| A/A |
6 |
1 |
|
| A allele frequency | 16.0% | 8.7% | 0.0004 |
*: unmethylated vs. methylated, #: frequency of GG homozygote.
NS: not significant.