Table 5.
Risk of −1018 GG homozygote for the development of CDH1 methylation
| Overall (527) | GG | GA | AA | GG vs A carrier; OR (95%C.I.) | p value |
|---|---|---|---|---|---|
| unmethylated (281) |
197 |
78 |
6 |
reference |
- |
| methylated (246) |
204 |
41 |
1 |
2.07 (1.35-3.17) |
0.0009 |
| non-GC (412) |
|
|
|
|
|
| unmethylated (262) |
180 |
76 |
6 |
reference |
- |
| methylated (150) |
125 |
24 |
1 |
2.25 (1.35-3.75) |
0.0019 |
| GC (115) |
|
|
|
|
|
| (non cancerous mucosa) |
|
|
|
|
|
| unmethylated (19) |
17 |
2 |
0 |
reference |
- |
| methylated (96) |
79 |
17 |
0 |
0.579 (0.120-2.80) |
0.50 |
| (cancer lesion) |
|
|
|
|
|
| unmethylated (37) |
30 |
7 |
0 |
reference |
- |
| methylated (78) | 66 | 12 | 0 | 1.50 (0.507-4.42) | 0.47 |
by logistic regression analysis after adjustment for age, gender and H. pylori infection status.
(): the number of subject.