Table 2.
Interaction between antipsychotic medications and COMT Val/Met polymorphism (rs4680) on cognitive functioning in bipolar patients (Met/Met as reference; psychopathology and time as fixed factors)
| Cognitive | Variable | Verbal | Memory | Selective | Attention | Working | Memory | Composite | Measure |
|---|---|---|---|---|---|---|---|---|---|
| N obs. |
|
419 |
|
384 |
|
416 |
|
379 |
|
| |
|
beta |
p-value |
beta |
p-value |
beta |
p-value |
beta |
p-value |
| COMT |
|
0.24 |
0.511 |
0.63 |
0.053 |
0.5 |
0.051 |
0.42 |
0.036 |
| Antipsych. |
|
−0.03 |
0.932 |
0.64 |
0.087 |
0.05 |
0.858 |
0.19 |
0.367 |
| MainInteract. |
|
−0.79 |
0.091 |
−1.1 |
0.024 |
−0.35 |
0.340 |
−0.79 |
0.004 |
| Stratified |
COMT = 0 |
|
|
0.64 |
0.087 |
|
|
0.19 |
0.367 |
| interaction |
COMT = 1 |
|
|
−0.47 |
0.141 |
|
|
−0.59 |
0.001 |
| BPRS |
|
−0.05 |
0.492 |
−0.02 |
0.835 |
−0.05 |
0.396 |
−0.04 |
0.385 |
| HDRS |
|
0.005 |
0.948 |
0.05 |
0.551 |
0.06 |
0.292 |
0.02 |
0.602 |
| YMRS |
|
0.002 |
0.972 |
0.12 |
0.029 |
0.07 |
0.061 |
0.06 |
0.063 |
| Time | 0.06 | 0.000 | 0.13 | 0.000 | 0.09 | 0.000 | 0.09 | 0.000 |