Table 2.
Results of the genetic association analyses for loge(CAC score + 1) using Metabochip SNPs (additive genetic model), gender and age as predictors in a linear regression model
|
CHR |
Gene |
SNP |
Physical position |
Minor allele (MAF) |
loge(CAC score + 1) |
loge(CAC +1) without CHD |
dichotomized CAC |
|||
|---|---|---|---|---|---|---|---|---|---|---|
| Beta (95% CI) | P | Beta (95% CI) | P | OR (95% CI) | P | |||||
| 9 |
CDKN2A/2B |
rs1537373 |
22093341 |
G (0.47) |
0.30 (0.21-0.39) |
4.05x10-11 |
0.26 (0.17-0.35) |
1.52x10-8 |
1.19 (1.07-1.31) |
0.001 |
| |
|
rs10965219 |
22043687 |
G (0.48) |
0.25 (0.16-0.39) |
1.32x10-7 |
0.23 (0.14-0.32) |
1.28x10-6 |
1.16 (1.05-1.29) |
0.005 |
| 6 | PHACTR1 | rs9349379 | 13011943 | G (0.39) | 0.30 (0.22-0.40) | 4.67x10-11 | 0.31 (0.22-0.40) | 3.48x10-11 | 1.26 (1.14-1.4) | 1.47x10-5 |
CHR Chromosome number; SNP single nucleotide polymorphism; MAF minor allele frequency from our data; 95% CI 95% confidence interval; CAC coronary artery calcium and CHD coronary heart disease.