Table 3.
Results of the genetic association analyses for loge(CAC score + 1) using Metabochip SNPs (additive genetic model) and age as predictors in a linear regression model for females and males
|
CHR |
Gene |
SNP |
Physical position |
Gender-SNP Interaction |
Females |
Males |
|
||
|---|---|---|---|---|---|---|---|---|---|
| Beta (95% CI) | P | Beta (95% CI) | P | Beta (95% CI) | P | ||||
| 9 |
CDKN2A/2B |
rs1537373 |
22093341 |
−0.07 (−0.25 to 0.11) |
0.44 |
0.27 (0.15-0.39) |
1.28x10-5 |
0.34 (0.21-0.47) |
6.76x10-7 |
| |
|
rs10965219 |
22043687 |
−0.23 (−0.41 to -0.06) |
0.01 |
0.13 (0.01-0.26) |
0.03 |
0.36 (0.23-0.50) |
1.25x10-7 |
| 6 | PHACTR1 | rs9349379 | 13011943 | 0.08 (−0.01 to 0.27) | 0.37 | 0.35 (0.23-0.48) | 3.5x10-8 | 0.27 (0.14-0.41) | 7.58x10-5 |
CHR Chromosome number; SNP single nucleotide polymorphism; MAF minor allele frequency from our data; 95% CI 95% confidence interval; CAC coronary artery calcium.