Figure 2.

Overexpression and activation of integrin beta1 induce gefitinib resistance via c-MET signaling pathway.A MTT analysis showed that activation of integrin beta1 by FN could induce gefitinib resistance. B TUNEL analysis showed that the apoptosis of PC9/D6 cells were decreased markedly after treated with FN. C Western blot analysis showed that ligand-dependent activation of integrin beta1 could increase phosphorylation of c-Met, FAK, and AKT in PC9/D6 cells. D Overexpression of integrin beta1 induces EGFR TKI resistance through increasing phosphorylation of c-MET and its downstream signals: FAK, AKT.