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. 2012 Nov 28;42(2):444–452. doi: 10.3892/ijo.2012.1715

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Copyright © 2013, Spandidos Publications

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Figure 5. — Effect of IAP knockdown by RNAi upon in vitro sensitivity to cisplatin. (A) JU77 XIAP (B) LO68 XIAP (C) ONE58 XIAP (E) JU77 survivin (F) LO68 survivin (G) ONE58 survivin. Cells were transfected with optimal RNAi duplexes and then incubated for 48 h for optimal knockdown and cultured in the presence of cisplatin (5 and 10 μg/ml) for 24 h. Cell viability was determined by MTT assay. Each bar represents the mean ± SD from three independent experiments. ^*There was a significant decrease in cell viability in ONE58 cells following survivin knockdown p<0.05 (Fisher’s t-test). Extent of IAP protein knockdown by RNAi: (D) XIAP (H) survivin. Cells were transfected as above and after 48 h assayed by cell ELISA for relative protein expression. Each bar represents the mean ± SD from two independent experiments.