Table 3.

Frequency of at Least One Adverse Effect by Age at Time of Infusion

	No. (%) of Infusions*
Adverse Event	All (n= 153)	≤ 1 mo (n= 19)	> 1 mo to 1 yr (n= 38)	>1 yr to 5 yr (n= 24)	> 5 yr to 12 yr (n= 37)	> 12 y (n= 35)
Hypotension	81 (53)	17 (89)	17 (45)	7 (29)	15 (41)	25 (71)
Bradycardia	38 (25)	4 (21)	18 (47)	4 (17)	8 (22)	4 (11)
Hypertension	14 (9)	0	0	5 (21)	3 (8)	6 (17)
Emesis	14 (9)	1 (5)	4 (11)	0	5 (14)	4 (11)
Respiratory depression	8 (5)	0	3 (8)	1 (4)	2 (5)	2 (6)
Arrhythmia	4 (3)	1 (5)	1 (3)	0	2 (5)	0
Other†	9 (6)	0	3 (8)	1 (4)	3 (8)	2 (6)

^*Some patients had more than one adverse event.

^†Other adverse events reported: seizure (3 events), status epilepticus, hallucinations, mydriasis, asystole, nausea, diarrhea.