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Summary of the Nav β-subunit structure and β3 constructs. A) All Nav β subunits possess a single extracellular Ig domain, a “stalk ” that links the Ig domain to a single α-helix transmembrane domain and an intracellular domain. In β3, the intracellular domain is largely disordered but has a juxtamembrane region with the potential to form a short amphipathic α helix (21). B) The epitope-tagged wild-type and mutant β3-subunit constructs that are referred to in the text.
