Table 7. Unique clusters potentially associated with the ca/ts phenotype. The P-values of all clusters in one sequence were checked against Bonferroni-corrected significance levels. For each Bonferroni correction, the total number of clusters located in the corresponding sequence was used (11 clusters in Arb/ca PB2, two clusters in Len/17/ca and Len/47/ca NS2, 11 clusters in Len/17/ca and Len/47/ca PA, ten clusters in Len/17/ca and Len/47/ca PB2, eight clusters in Len/47/ca NP, 11 clusters in Len/wt PB2).
| Strain | Sequence | Position | Occurrence in the random data seta | 95% confidence intervalb | P-value |
|---|---|---|---|---|---|
| Arb/ca |
PB2 |
329–336 |
15 |
[0.0, 0.023] |
3.34E-09 |
| Len/17/ca |
NS2 |
290–308 |
16 |
[0.0, 0.024] |
1.11E-08 |
| Len/17/ca |
PA |
93–101 |
32 |
[0.0, 0.043] |
0.0037 |
| Len/17/ca |
PB2 |
1293–1310 |
9 |
[0.0, 0.016] |
5.24E-13 |
| Len/47/ca |
NP |
1017–1026 |
29 |
[0.0, 0.039] |
0.0007 |
| Len/47/ca |
NP |
1178–1192 |
29 |
[0.0, 0.039] |
0.0007 |
| Len/47/ca |
NS2 |
290–308 |
16 |
[0.0, 0.024] |
1.11E-08 |
| Len/47/ca |
PA |
93–101 |
32 |
[0.0, 0.043] |
0.0037 |
| Len/47/ca |
PB2 |
808–818 |
3 |
[0.0, 0.008] |
1.36E-18 |
| Len/wt | PB2 | 1490–1629 | 982 | [0.973, 1.0] | 1.03E-07 |
a The number of times a particular cluster was found in a data set of 1000 sequences with randomly introduced mutations. bEstimated range of values which is likely to include the probability to find a particular cluster with the probability of 95%.