Table 4. Area and size of liver tumorsa.
Tumor Number (tumor/mouse) | Total Tumor Area (in mm3/per tumor bearing mouse)b | Tumor Size (in mm3/tumor per tumor bearing mouse)b | |||||
Genotype | Group | Adenomas | Carcinomas | Adenomas | Carcinomas | Adenomas | Carcinomas |
TGFα/TrsptG37 | 1B | 0.7±0.8 | 1.1±1.4 | 40±14b | 556±121 | 36±12 | 331±55 |
1C | 0.6±0.9 | 0.9±1.2 | 10±6 | 272±69 | 8±5 | 174±40 | |
1D | 0.6±0.8 | 0.9±1.0 | 15±9 | 388±33 | 12±8 | 229±20 | |
TrsptG37/+ | 2B | 0.3±0.5 | 0 | 10±11 | 0 | 10±11 | 0 |
2C | 0.3±0.4 | 0 | 10±2 | 0 | 10±2 | 0 | |
2D | 0.6±0.9 | 0.06±0.24 | 15±4 | 79 | 13±3 | 79 | |
TGFα/+ | 3A | 0.3±0.5 | 0.5±0.7 | 5±4 | 222±35 | 5±4 | 187±35 |
3B | 0.7±0.7 | 0.7±0.7 | 23±8 | 469±106 | 20±8 | 388±106 | |
3C | 0.8±0.8 | 0.6±0.8 | 18±9 | 188±20 | 15±7 | 145±20 | |
3D | 0.7±1.0 | 0.8±0.8 | 21±9 | 191±50 | 14±4 | 155±50 | |
3E | 0.6±0.8 | 0.7±0.8 | 30±10 | 170±38 | 27±9 | 142±38 | |
+/+ | 4A | 0 | 0 | 0 | 0 | 0 | 0 |
4B | 0.5±0.8 | 0.3±0.8 | NAc | NAc | NAc | NAc | |
4C | 0.3±0.7 | 0 | NAc | 0 | NAc | 0 | |
4D | 0.1±0.3 | 0.1±0.3 | NAc | NAc | NAc | NAc | |
4E | 0 | 0.3 | 0 | NAc | 0 | NAc |
Tumor number (see Table 3), size, and area were assessed at necropsy and compared using least square means procedures (see text). Tumor numbers are shown as raw means ± standard deviations. The sizes of approximately 15% of tumors were not measured, including all tumors for Group 4.
Tumor area and size are shown as geometric means ± standard deviations.
NA, no size measure for tumors available.