Table 1. Upregulated expression of 1q genes in breast ductal carcinoma.
| Gene Symbol1 | Gene Name | Chromosome position2 | SAGE3 cancer (A) | SAGE3 normal (B) | Normalised Odds A:B4 | EST5 cancer (A) | EST6 normal (B) |
| UBAP2L | Ubiquitin associated protein 2-like | 1q21.3 | 12 | 0 | ∞ | − | − |
| QSOX1 | Quiescin Q6 sulfhydryl oxidase 1 | 1q24 | 10 | 0 | ∞ | + | − |
| PVRL4 | Poliovirus receptor-related 4 | 1q22–q23.2 | 9 | 0 | ∞ | − | − |
| ACBD3 | Acyl-Coenzyme A binding domain containing 3 | 1q42.12 | 9 | 0 | ∞ | − | − |
| GLUL | Glutamate-ammonia ligase (glutamine synthetase) | 1q31 | 29 | 1 | 16.27 | + | − |
| CCT3 | Chaperonin containing TCP1, subunit 3 (gamma) | 1q23 | 14 | 1 | 7.85 | + | − |
| SLC30A1 | Solute carrier family 30 (zinc transporter), member 1 | 1q32–q41 | 13 | 1 | 7.29 | − | − |
| UCHL5 | Ubiquitin carboxyl-terminal hydrolase L5 | 1q32 | 37 | 3 | 6.92 | − | − |
| PI4KB | Phosphatidylinositol 4-kinase, catalytic, beta | 1q21 | 11 | 1 | 6.17 | − | − |
| GPATCH4 | G patch domain containing 4 | 1q22 | 11 | 1 | 6.17 | + | − |
| TMCO1 | Transmembrane and coiled-coil domains 1 | 1q22–q25 | 16 | 2 | 4.49 | + | − |
| GUK1 | Guanylate kinase 1 | 1q32–q41 | 23 | 3 | 4.30 | + | − |
| MAPKAPK2 | Mitogen-activated protein kinase-activated protein kinase 2 | 1q32 | 28 | 5 | 3.14 | − | − |
| S100A14 | S100 calcium binding protein A14 | 1q21.3 | 89 | 16 | 3.12 | − | − |
| RPS6KC1 | Ribosomal protein S6 kinase, 52 kDa, polypeptide 1 | 1q41 | 20 | 4 | 2.81 | − | − |
| ZNF669 | Zinc finger protein 669 | 1q44 | 44 | 10 | 2.47 | − | − |
| CRABP2 | Cellular retinoic acid binding protein 2 | 1q21.3 | 28 | 7 | 2.24 | + | − |
| HAX1 | HCLS1 associated protein X-1 | 1q21.3 | 21 | 6 | 1.96 | − | − |
| PSMD4 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 | 1q21.3 | 17 | 5 | 1.91 | − | − |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific) | 1q32.2 | 10 | 3 | 1.87 | − | − |
| H3F3A | H3 histone, family 3A | 1q41 | 57 | 18 | 1.78 | − | − |
| ENSA | Endosulfine alpha | 1q21.3 | 22 | 7 | 1.76 | + | − |
| LMNA | Lamin A/C | 1q21.2–q21.3 | 132 | 43 | 1.72 | + | − |
| TAGLN2 | Transgelin 2 | 1q21–q25 | 64 | 21 | 1.71 | + | − |
| F11R | F11 receptor) | 1q21.2–q21.3 | 142 | 51 | 1.56 | + | + |
The genes are listed in the order of degree of overexpression in cancer tissue. For all genes listed, the significance factor is P≤0.01.
From Unigene (http://www.ncbi.nlm.nih.gov/UniGene).
Total number of short SAGE tags identified for each individual gene.
The sequences Odds ratio is obtained by calculating normalised values of expression of each gene (total number of SAGE tags divided by the total number of tags in each library: 66,128 tags in the breast ductal carcinoma library and 50,512 tags in normal epithelium), and then calculating the ratio of these values (normalised expression in cancer over normalised expression in normal tissue). For the four top entries gene expression was not detected in normal tissues (SAGE only).
Based on ten non-normalised cDNA EST libraries from cancer breast tissues (not cell lines), totalling 11,161 sequences available.
Based on two non-normalised cDNA EST libraries from normal breast tissues (not cell lines), totalling 1,485 sequences available.