Table 1. Molecules described as γδ TCR ligands. List of molecules (with respective biochemical nature) proposed to bind directly to γδ TCRs in a particular human γδ T-cell subset or clone. The published evidence (PMID provided) was based on anti-γδ TCR blocking antibodies, γδ TCRtransfection experiments, surface plasmon resonance or co-crystallization studies.
| Molecule(s) | Biochemistry | γδcell subset | PubMed ID (references) |
|---|---|---|---|
| DRw53 + C. tetani peptide |
MHC-II + peptide |
Vγ9Vδ2 |
2469770, 1345917, 2524009 |
| Staphylococcal enterotoxin A |
superantigen |
Vδ2 |
8144918, 2377230 |
| Staphylococcal enterotoxin B |
superantigen |
Vδ1 |
8696008 |
| Oxidative stress response regulatory protein (OXYS) |
Bacillus Calmette-Guerin protein |
|
21526117 |
| Apolipoprotein A-I |
Lipoprotein |
Vγ9Vδ2 |
15664160 |
| Ecto-F1-ATPase (+ ApppI) |
Mitochondrial ATPase domain |
Vγ9Vδ2 |
15664160, 20483757 |
| Phosphoantigens (+ undefined presenting molecule) |
Prenyl pyrophosphates (bacterial/ mammalian) |
Vγ9Vδ2 |
7584140, 7529807, 18802083 |
| MutS homolog 2 (hMSH2) |
DNA repair protein |
|
18321859, 22433851 |
| Histidyl-tRNA synthetase |
tRNA synthetases (bacterial/ mammalian) |
Vγ1.3Vδ2 |
22549773 |
| Heat shock protein 60 (HSP-60) |
Heat shock protein (bacterial/ mammalian) |
Vγ9Vδ2 |
2473405, 1978758, 8094731, 18321859 |
| MICA |
MHC-Ib protein |
Vδ1+ |
12133944, 16297874, 9497295 |
| ULBP-4 |
MHC-Ib protein |
Vδ2+ |
19436053 |
| CD1c |
MHC-Ib protein |
Vδ1+ |
10727456, 2477705, 1690662, 12486100 |
| CD1d + sulfatide |
MHC-Ib protein + lipid |
Vδ1+ |
22829134 |
| Endothelial protein C receptor (EPCR) | MHC-Ib protein | Vγ4Vδ5 | 22885985 |