Table 1. Estimated Type I Error Rate and Statistical Power.
Type I error rate |
Statistical power |
||||||
---|---|---|---|---|---|---|---|
Distra | Methodb | α = 0.10 | α = 0.05 | α = 0.01 | α = 0.10 | α = 0.05 | α = 0.01 |
Exp | Permut | 0.191*** | 0.113*** | 0.028*** | 0.493 | 0.387 | 0.235 |
Bootstr | 0.145*** | 0.078*** | 0.022*** | 0.451 | 0.360 | 0.235 | |
GeneDr | 0.108 | 0.045 | 0.009 | 0.402 | 0.312 | 0.164 | |
GRAIP | 0.116* | 0.052 | 0.012 | 0.416 | 0.315 | 0.164 | |
Norm | Permut | 0.129*** | 0.059 | 0.012 | 0.478 | 0.379 | 0.241 |
Bootstr | 0.090 | 0.048 | 0.007 | 0.409 | 0.343 | 0.223 | |
GeneDr | 0.090 | 0.051 | 0.010 | 0.416 | 0.355 | 0.239 | |
GRAIP | 0.086* | 0.044 | 0.010 | 0.418 | 0.342 | 0.217 | |
Unif | Permut | 0.136*** | 0.079*** | 0.014 | 0.488 | 0.397 | 0.241 |
Bootstr | 0.104 | 0.057 | 0.011 | 0.435 | 0.352 | 0.219 | |
GeneDr | 0.104 | 0.062* | 0.011 | 0.429 | 0.351 | 0.220 | |
GRAIP | 0.105 | 0.060 | 0.011 | 0.430 | 0.352 | 0.246 |
Allele (A/a) frequencies at the founder generation: 3/1 for F26 vs. 1/3 for F34. Estimated from 1200 simulations at genome-wide significance level α = 0.10, 0.05 or 0.01. *, **, and *** indicate that the estimated type I error rate is significantly different from the expected significance levels 0.10, 0.05, and 0.01, respectively.
Residual distribution: exponential (Exp), normal (Norm), or uniform (Unif).
Permuting marker data (Permut), bootstrapping phenotypic data (Bootstr), or gene dropping (GeneDr).