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. 2013 Feb 27;8(2):e58052. doi: 10.1371/journal.pone.0058052

Figure 5. Potential Functions and Regulation of PRAME.

Figure 5

Activation of TLRs and other signalling receptors by PAMPs and cytokines associated with infections or tumours (1) results in both transcriptional (2) and translational (3) upregulation of PRAME. Cytoplasmic PRAME can associate with Elongin proteins located in the Golgi/ER network (4). Association of PRAME with intracellular PAMPs or other molecules (5) may facilitate their targeting to the Golgi for modification, secretion or destruction by Elongin/Cullin Ubiquitin ligases (6). Interactions of PRAME proteins with Elongins, Cul2 or Histone H3 in the nucleus (7) may be involved in the regulation of gene expression.