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. 2013 Feb 27;8(2):e57777. doi: 10.1371/journal.pone.0057777

Figure 1. Structure of the microsimulation model at the individual level.

Figure 1

Circle: event that does not determine a change of line of treatment. Rhombus: event that determine a change of line of treatment. HS: Health State. CHD: Coronary heart disease. CKD: Chronic kidney disease. OI: Opportunistic infection. VL: Viral load. § event that may lead to death. * Detectable viral load for two consecutive semesters. Patients enter the model being in first-line treatment (LPV/r or ATV+r). After each cycle, patients may change health state, die or experience events that may lead to a change in the line of treatment (patients in second-line had different treatment options that excluded those on first-line). Diarrhoea and hyperbilirubinemia may be experienced only by patients in first-line treatment, since these adverse events are associated with LPV/r and ATV+r therapies.