Table 2. Transition probabilities (per patient, per 6-month cycle) related to first-line treatment and second-line treatment and probabilities of AIDS event.
Health state | CD4 (cell count /mL) | HIV RNA (copies/mL) | Transition ProbabilitiesLPV/r (first line)† | Transition Probabilities ATV+r 1 (first line)† | Transition Probabilities ATV+r 2* (first line)† | Transition Probabilities (second line)† | AIDS probabilities |
1 | > 350 | < 50 | 0.70721 | 0.77487 | 0.7232 | 0.49504 | 0.0009 |
2 | > 350 | ≥ 50 | 0.86111 | 0.71106 | 0.86980 | 0.60277 | 0.0162 |
3 | 201–350 | < 50 | 0.38737 | 0.29664 | 0.40847 | 0.27118 | 0.0104 |
4 | 201–350 | ≥ 50 | 0.45253 | 0.36481 | 0.47386 | 0.31675 | 0.0585 |
5 | 50–200 | < 50 | 0.05202 | 0.08941 | 0.05719 | 0.0364 | 0.0212 |
6 | 50–200 | ≥ 50 | 0.13132 | 0.09041 | 0.14281 | 0.09191 | 0.2276 |
7 | < 50 | < 50 | 0.01623 | 0.00485 | 0.01791 | 0.01134 | 0.6934 |
8 | < 50 | ≥ 50 | 0.02844 | 0.02175 | 0.03135 | 0.01988 | 0.9435 |
diagonal elements of transition matrix expressing the probability of remaining in the same health state after one Markov cycle (semester)
transitions based on a 19% lesser likelihood of transitioning to a state with greater viral load than when receiving LPV/r