Table 2. Univariate and multivariate analyses of prognostic factors and RCC survival.
| OS | DFS | |||||||
| Subject characteristics | Univariate | Multivariate | Univariate | Multivariate | ||||
| OR (95% CI) | p† | OR (95% CI) | p† | OR (95% CI) | p† | OR (95% CI) | p† | |
| ERβ expression high/low * | 0.114 (0.027–0.490) | 0.004 | 0.118 (0.015–0.916) | 0.041 | 0.095 (0.022–0.408) | 0.002 | 0.082 (0.011–0.636) | 0.017 |
| Age | 0.991 (0.961–1.021) | 0.546 | - | - | 0.987 (0.959–1.016) | 0.370 | - | - |
| Gender – Male/Female | 2.641 (0.893–7.810) | 0.079 | - | - | 2.937 (1.003–8.599) | 0.049 | 3.133 (0.675–14.545) | 0.145 |
| Laterality left/right | 1.104 (0.477–2.556) | 0.818 | - | - | 1.095 (0.490–2.446) | 0.826 | - | - |
| TNM stage III + IV/I + II | 5.077 (1.801–14.312) | 0.002 | 3.595 (1.155–11.188) | 0.027 | 5.020 (1.909–13.196) | 0.001 | 3.290 (1.118–9.681) | 0.031 |
| Grade G3 + G4/G1 + G2 | 3.640 (1.230–10.766) | 0.020 | 1.441 (0.421–4.930) | 0.560 | 3.075 (1.146–8.251) | 0.026 | 1.070 (0.331–3.464) | 0.910 |
| Chemotherapy (no vs. yes) | 2.300 (0.680–7.782) | 0.180 | - | - | 2.141 (0.636–7.212) | 0.219 | - | - |
| Radiotherapy (no vs. yes) | 1.511 (0.557–4.096) | 0.417 | - | - | 1.789 (0.710–4.512) | 0.218 | - | - |
*
Categorized as low (≤mean) and high (>mean) was separated at ERβ >22% positivity (high) and ERβ ≤22% positivity (low).
†
Analyzed with the Cox hazard regression model. Statistical significance (p<0.05) is shown in boldface. n.a.: not analyzed.
Abbrev: RCC: renal cell carcinoma, OR: odds ratio, CI: confidence interval, OS: overall survival, DFS: disease-free survival, ER: estrogen receptor.